The Igh Podcast

Malaria is a disease usually associated with the tropics. However, avian malaria, caused by similar parasites, is distributed worldwide with the exception of Antarctica. Avian malaria is spread by biting mosquitoes. The impact of the disease on bird populations varies. Some birds will not show any symptoms, but other populations can be driven to extinction by avian malaria. Zoos in particular have suffered from avian malaria outbreaks. London Zoo lost six penguins in 2012 and Longleat took the decision to close their penguin exhibit in 2018 after a second outbreak called into question the viability of keeping penguins. Despite these problems, little is known about the distribution of mosquitoes around zoos and their ability to infect birds with avian malaria. This month we spoke to Arturo Hernandez Colina about his work looking into avian malaria in the UK.

Acute encephalitis describes a rapidly developing inflammation of the brain and, as you can imagine, is a neurological emergency. Not only is it a life-threatening disease with a mortality rate of up to 15%, it also presents a unique diagnostic challenge for doctors. Patients presenting to the emergency room with common symptoms of encephalitis such as fever, confusion or seizures, could have any number of other conditions which mimic these symptoms. With roughly 6,000 cases per year, encephalitis is relatively rare compared to, say, drug or alcohol misuse which can present in a similar way. As a result, Even once encephalitis is diagnosed there is a further complication. Inflammation can be caused by an external factor, in the case of encephalitis this is usually a virus, but it can also be caused by autoimmune disease in which the body develops an immune reaction against its own proteins. In cases of autoimmune disease, the aim of treatment would be to suppress the immune system and prevent it from caus

We’ve spoken in previous episodes about zoonotic diseases such as Leptospirosis and Echinococcus. The term zoonosis, which describes diseases that can affect both animals and people, was coined by a German scientist, Rudolf Virchow, working in the 19th century. Virchow could be considered the founder of the One Health approach to medicine and research. He stated that “Between animal and human medicine there are no dividing lines – nor should there be. The object is different but the experience obtained constitutes the basis of all medicine”. This concept that human health is inextricably linked to that of animals is the central tenant of One Health which aims to design and implement research, programmes and policy to improve public health. This approach requires collaboration across a wide variety of disciplines from the medical and veterinary fields. The result is a series of large research projects involving multiple research institutes across several countries. One Health projects can have a particularl

Parasites come in all shapes and sizes. Some of them can live in their host without causing symptoms whilst others cause debilitating and sometimes fatal disease. A few episodes ago, we talked about lungworm in cattle. While lungworm can affect other species as well, like deer and buffalo, they tend to be closely related to cattle. However, other parasites make a habit of infecting different species as part of their lifecycle. Rather than having a free-living life cycle, which leaves them at the mercy of the elements, they take up residence in an intermediate host. Here they are relatively safe and can busy themselves preparing to infect their definitive host where another round of reproduction will take place.   A good example of these types of parasites are Echinococcus, a genus of Cestodes which are more commonly known as tapeworms. This type of tapeworm tends to use livestock as an intermediate host and predatory species, such as canids, as their definitive host. They have an important role in human he

Dogs are currently the most popular pet in the UK forming 26% of the pet population. Pet ownership has been associated with health benefits such a reduced blood pressure, increased exercise and reduced feelings of loneliness. However, dog bites are also believed to be on the increase and, over the last five years, Merseyside has become the dog bite capital of the UK with the greatest number of dog related hospital admissions per 100,000 population. Recently reported figures suggest that at least 20 people are hospitalised due to dog bites every day in England and Wales. Dog bites can have a devastating impact on all parties involved. Most obviously, the person bitten is left with a physical injury and, perhaps a lasting fear of dogs. These can lead to personal economic losses through time off work. The dog itself is often euthanised after a serious bite which in turn impacts the owner. Even if the dog isn’t euthanised, it may be confiscated or given up to a shelter since the owner feels they can no longer

The bovine lungworm, or Dictyocaulus viviparus, inhabits the lungs of cattle causing a disease known as husk. The symptoms include coughing and an increased breathing rate. Severely affected cows may be reluctant to move and struggle to breath with some heavy infections leading to death. Of course, all of these symptoms are accompanied by production losses and decreased animal welfare which both have an impact on farmers. The cost of an outbreak has been estimated at about £140 per cow in the herd. Traditionally, lungworm was a disease which affected young cattle in the south-west and the Midlands. Over the few decades there has been a shift in the pattern of lungworm epidemiology with an increase in Scotland and northern England. In 2014 the Department for Environment, Farming and Rural Affairs and the national disease surveillance networks such as APHA released a statement expressing concern at the increased incidence of lungworm in these areas. Not only did the number of cases increase, but there were m

Leptospirosis is an important disease worldwide. Not only does it affect seven to ten million people annually, it also infects animals causing economic and personal loses. The disease itself is caused by a genus of bacteria called Leptospira with up to 13 different genetic types of Leptospira able to cause disease. In the UK, an important reservoir for leptospirosis is cattle. Not only does this cause problems in terms of cattle health, but can also pose a public health risk to the farmers who look after them. In terms of cattle health, leptospirosis can be tricky to diagnose and treat. The symptoms, such as reduced milk production, abortion, weak calves and other fertility problems, are not unique to leptospirosis so can be challenging to diagnose. What’s more, not all cattle with show obvious clinical signs with some affected by subclinical disease which is difficult to detect. Further complicating the picture is the fact that Leptospira can live in the kidneys of recovered cows for years without causing

Antimicrobial resistance is one of the major challenges facing us today. Not only does it have implications for human medicine and disease control but how and when we decide to use antibiotics to treat disease in animals. The agriculture industry has come under widespread pressure to reduce and replace antibiotics in food production animals. However, antibiotic use is widespread in small animal medicine too. One important aspect of tackling antimicrobial resistance is understanding when antibiotics are prescribed and identifying areas in which their use can be reduced. Farmers should keep detailed records of antibiotic use, but there is used to be no integrated system for collecting data associated with antibiotic use in small animals. In 2008, the Small Animal Veterinary Surveillance Network or SAVSNET was set up by the British Small Animal Veterinary Association and the University of Liverpool. Since then SAVSNET has expanded to include over 200 veterinary practices at around 450 premises submitting anon

Lameness in dairy cattle is a well known issue with plenty of research exploring the effects on animal health and welfare, as well as the economic impact for farmers. However, lameness in the UK beef herd is less well characterised. Identifying the current levels of lameness and the main causes is the first step in developing an approach to reducing lameness in beef cattle. Another essential aspect is farmers’ perceptions of the problem. Ultimately, the farmer is responsible for the health and welfare of their animals. In terms of reducing lameness, farmers’ efforts to reduce disease incidence might be hampered if they haven’t recognised lameness as a problem or have trouble identifying clinical cases. This month we talked about lameness in beef cattle, and farmers’ perceptions of the problem with Jay Tunstall, a PhD student at IGH who recently published a paper entitled “Lameness in Beef Cattle: UK Farmer’s Perceptions, Knowledge, Barriers and Approaches to Treatment and Control.” https://www.frontiersin.

The brown rat doesn’t have a good reputation in our culture. This episode probably won’t do much to help their cause and shed the popular perception of the rat as a disease-carrying pest. Although they’re intelligent and social animals that love to be tickled and can make great pets, they are known carriers of several different diseases. Some of these pose no threat to humans or their livestock, but others are known or possible disease causing agents. As a result, it’s important to monitor which viruses and bacteria are circulating in wild rodent populations so we can act before they cause a problem. Once we know that a virus or bacteria is present in wild rodents and could cause a threat, we can take steps to prevent that from developing. Here to tell us about her work looking at the viruses and bacteria in wild rodent populations is Ellen Murphy. She’s coming to the end of her PhD at the moment and is busy writing up her thesis, but she’s kindly agreed to tell us about her research.  

“By 2040, our vision is of a world in which antimicrobial resistance is effectively contained and controlled...” So says the British Government. That sounds great but veiled beneath the vision is the suggestion that if we continue on our current course, antimicrobial resistance isn’t being effectively contained and controlled at present. Over the past few decades infections caused by antimicrobial resistant ‘superbugs’ have caused 700,000 deaths globally. If no action is taken, that figure is expected to rise to 10 million by 2050 with a cumulative cost of $100 trillion dollars. Antimicrobial resistance is a global problem and we all have to understand what we can do to help the cause either as a health professionals, patients or members of the public. In this episode we talk to Dr Jennie Wilson, Vice President of the Infection Prevention Society. Jennie is a Professor of Healthcare Epidemiology at the University of West London. She is an experienced infection control practitioner with extensive knowledge of

Salmonella is perhaps one of the best known bacteria around. There are more than 2,500 strains of Salmonella bacteria. They live in the guts of many different animals, wild and domestic including cows, pigs, snakes and, of course, chickens. They’re also a cause of food poisoning in the UK. There were 8,451 cases of Salmonella food poisoning in 2015, but this is down from 14,465 cases in 2000. While you can catch Salmonella from a variety of sources, we were always told that eating raw and poorly cooked eggs was risky. But in October, the Food Standards Agency said that raw and lightly cooked eggs with the British Lion mark were now safe for vulnerable people ,like pregnant women and young children, to eat. This was after a consultation found that “there has been a major reduction in the risk from Salmonella in UK hens’ eggs since 2001”. But what caused this change in advice? What actually is Salmonella and what’s the relation to the British Lion mark? We’re here today with Professor Paul Wigley, Professor

Infectious diseases have affected more than just how people have died over the centuries. They have contributed to the development of our culture, language and behaviours. This is especially true of our interactions and relationships with animals. One animal with which we’ve had an uneasy relationship with is the rat. Society has associated rats with disease even before we recognised their role as disease carriers or vectors. But recently, the rat has begun to come out of the shadows. In the UK, we’ve begun to welcome domesticated rats into our homes as pets. The Pet Food Manufacturers Association estimated that there were 200,000 pet rats in the UK in 2012. That makes them as popular as tortoises and twice as numerous as gerbils and horses. However, while many people have given a rat a home they would probably not be as enthusiastic about an uninvited wild rat moving in. So what is it that makes us distinguish between domestic and wild rats, with one being considered a friend and the other an undesirable?

Rotavirus is a highly infectious disease that usually affects babies and young children. Globally, it is the leading cause of severe diarrhoea among infants. In fact, the virus is so ubiquitous that the Centre for Disease Control in the US estimated that prior to rotavirus vaccination programs starting, almost all U.S children were infected with rotavirus before their 5th birthday. The effects of the virus, mainly watery diarrhoea sometimes accompanied by vomiting, tummy ache and fever; might not sound too bad for adults. However, diarrhoea in infants can quickly lead to extreme dehydration and other complications. As many as 1 in 10 children who contract rotavirus will end up in hospital as a result of the disease. In 2013, the WHO estimated that rotavirus caused around 215,000 deaths in children younger than 5 years old during. A safe and effective oral vaccine became available in the UK in 2013 after which rotavirus cases reduced by 69%. The vaccine is free of charge and delivered in two doses at 8 and