Science In Action

The 2023 Nobel Prize in Physiology or Medicine was awarded to Katalin Karikó and Drew Weismann for their contributions to developing the fundamentals that led to life saving mRNA vaccines. Although funding and support were not always assured on their road to the Nobel, Katalin Karikó tells Roland she used these setbacks to drive her towards success. On the other side of the coin, allegations of scientific misconduct over bold room temperature superconductivity claims. Earlier this year, eleven authors submitted a paper to Nature. Now, eight of them are calling for a retraction. Science journalist Dan Garisto covers the story. Also this week, NASA Ames researcher Jacob Kegerreis details how Saturn got its rings. Hint: It’s a smashing story. And, what is the most fear inducing sound in the world? Lions roaring? Gunshots? According to mammals in South Africa it is the human voice. Fear-ecologist Liana Zanette explains. Presenter: Roland Pease Producer: Ella Hubber Editor: Martin Smith Production Co-

What did a 465-million-year-old trilobite eat for dinner? And how can we possibly know? Archaeologist Per Ahlberg has used x-ray to peer into the guts of one ancient scuttling creature and worked out what it what was munching on in its final moments. From life in ancient earth rocks to potential life in space rocks, mineralogist and astrobiologist Bob Hazen has been training AI to spot signatures of life on Earth. He now hopes to use this tool on space samples. We also ask experimental particle physicist Jeffrey Hangst how antimatter, the last mystery of the universe, responds to gravity - was Einstein's theory of general relativity right? And the antiviral Covid medication, Molnupiravir, may be causing the virus to mutate. Theo Sanderson discusses how he figured this out and how concerned we should be. Presenter: Roland Pease Producer: Ella Hubber Editor: Martin Smith Production co-ordinator: Jana Bennett-Holesworth (Image: Fig. 1: Bohemolichas incola (Barrande, 1872). Credit: Kraft et al)

Storm Daniel devastated the city of Derna in Libya after heavy rainfall broke a dam, causing extreme flooding downstream. The World Weather Attribution (WWA) reports that severe flooding in Libya and across the Mediterranean has been made more likely and more intense due to human induced climate change. WWA scientist Friederike Otto gets into the report. Back in 2020, NASA’s OSIRIS-REx scooped up rock and dust samples from asteroid Bennu and on Sunday September 24th, 2023 the sample capsule will finally be released 100,000 kilometres above Earth, delivering it to the Great Salk Lake Desert. OSIRIS REx engineer Anjani Polit tells us about the nail-biting return. Also this week, Dr Peter Hotez warns us about the dangerous and rapid rise of anti-science sentiment in the United States. It’s all in his new book "The Deadly Rise of Anti-Science". And the remnants of what is thought to be the oldest wooden structure have been found in Zambia. Professor of Archaeology Lawrence Barham talks about the simple structure

Earlier this week the deadly Mediterranean cyclone, Storm Daniel, swept through the small city of Derna in Libya, collapsing a 50-year-old dam in its wake, and triggering devastating floods which have killed over 5000 people. We speak to atmospheric scientist, Stavros Dafis, about the cyclone’s characteristics and to civil and structural engineer, Lis Bowman, about the dam collapse. Unsurprisingly, it all comes back to climate change. Far, far from Earth, the James Webb Space Telescope has set its site on the atmosphere of exoplanet K2-18b where the presence of methane and carbon dioxide offer the tantalising possibility of an extraterrestrial Ocean. Astrophysicist Nikku Madhusudhan discusses his exciting results. And an even less expected presence in space: the ancient remains of our ancestors. Archaeologist Lee Berger has come under fire after sending precious bone samples on a Virgin Galactic space flight. South African archaeologist, Robyn Pickering, expresses the frustration that is on everyone’s mind.

In September 2012 Arctic sea ice melted to its minimum ever recorded and the German research ice breaker, Polarstern, ventured deep into the region North of Russia to record findings. It’s now retracing its steps, over a decade later, to observe how things have progressed. Autun Purser and Antje Boethius describe the journey and the importance of documenting developments in the face of climate change. Some 75 million individuals are believed to live with Long Covid and, in order to treat the plethora of symptoms presented by patients, researchers continue to search for the root source of the condition in the hope of better prescribing broad therapeutics. Akiko Iwasaki, Professor of Immunobiology at Yale University, updates Roland on the working hypotheses. And one year on from the Hunga Tonga eruption, where a shockwave circled the globe four times, researchers have been able to calculate the speed of the currents in the southern Pacific Ocean. BBC correspondent Jon Amos caught up with Michael Clare to hear h

Global sea levels are rising more than 3mm per year under current climate conditions. At this rate we are due to hit an alarming 7mm rise per year by the end of the century. If this is not slowed, it could lead to the drowning of essential coastal ecosystems like mangroves and lagoons, professor of environmental science Neil Saintilan tells Science in Action. The seas are also heating up. We’ve covered the devastating effect of marine heatwaves on vibrant sea life like coral reefs before. But what about the less glamourous bottom-dwelling fish? Ecologist Alexa Fredston has found that they may be more robust than we think. Also this week, bird virus expert Michelle Wille tells us about the imminent threat of bird flu spreading from South America to Antarctica where hundreds of thousands of sea birds are at risk. And from one south pole to another, we have an update on how India’s mission on the lunar south pole is going with Lunar and Planetary Institute scientist David Kring. Image Credit: Marie HickmanPrese

Advances in brain-computer interfaces have allowed patients with paralysis to communicate faster, more accurately and more expressively with direct brain to speech translation. Co-author of an exciting new paper in the field, bioengineer Alex Silva, tells Science in Action about his team’s work with patient Ann. The world has been following the Indian and Russian race to land on the lunar south pole. Producer Ella Hubber gives a timeline of the events leading up to that historic landing. Also this week, a new prediction model allows us to better prepare for future extreme weather events. But is this worst-case scenario model scaremongering? Roland talks to author Erich Fischer about the projections. And virologist Connor Bamford talks detecting bird flu in wastewater for betting monitoring.Image Credit: Noah BergerPresenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings

Hawaii is still reeling from the devastating fires that consumed Lahaina on the island of Maui last week. Professor of Meteorology from the University of Hawaii, Kevin Hamiliton, joins Science in Action to discuss the factors that make these events more likely across the Hawaiian Islands. Amongst these is climate change. Also this week we discuss the concerning reports of a sudden spike in methane levels in the Arctic with Xin Lan of the US National Ocean and Atmospheric Administration. A few weeks ago, we devoted a whole programme to the exciting research on human embryo models made from stem cells. Whilst representing an incredible step for medical research, these raise serious ethical questions. A team of biologists and embryologists have put together a proposal on how to move forward with this ethical quandary, Embryologist Nicolas Rivron tells us more.And we address the incredible claim of the room temperature super conductor, LK-99, with sceptical materials scientist Michael Fuhrer.Photo: The Maui town

ProMED is one of the most useful scientific tools you’ve never heard of. It’s a global surveillance system of infectious disease outbreaks which is available, for free, to researchers and the public alike. But ISID, the society which runs the platform, claim they have run out of money to support ProMED and will be switching to a subscription service, against the wishes of both users and staff. ProMED editor Marjorie Pollak tells Science in Action about the vital service ProMED has played in pandemic monitoring – including the very first COVID outbreaks - and ISID boss Linda MacKinnon considers what’s next for the platform. From wildfires in Europe to droughts in Africa, we have covered every kind of environmental disaster across most of the globe in the space of the past few weeks. To complete the distressing bucket list of climate extremes, we’re talking to sea ice expert Caroline Holmes on the concerning forecast for Antarctica. Despite these terrestrial challenges, NASA is still trying to defend Earth agai

Science in Action returns to H5N1, the fast spreading strain of bird flu which has caused devastation in the sky, sea, and land over the last few months, with no end in sight. Roland visits Skomer Island and the coast of Wales where sea bird colonies are threatened and hundreds of guillemots have washed ashore dead, struck down by bird flu. We also hear of outbreaks on Finnish fur farms where controversial plans are in progress for culls of wild birds, of mysterious infections of domestic cats in Poland, and bird flu causing brain swelling in grey seals. Plus, we get an update on efforts to vaccinate condors in California against the disease.Photo: Dead Guillemot Credit: BBCPresenter: Roland Pease Producer: Ella Hubber

A large system of ocean currents known as the Atlantic meridional overturning circulation (AMOC) has been making headlines this week as a new paper predicts its imminent collapse. This could have devastating consequences for the climate. But not all climate scientist and oceanographers are convinced by the results. Stefan Rahmstorf and Eleanor Frajka-Williams debate the contentious paper.In more positive news, huge steps have been made in the field of gene therapy. Stefano Rivella and Hamideh Parhiz tell us about their incredible mRNA delivery technology which could take much of the cost and risk out of treating debilitating disordersAnd as wildfires continue to blaze around the world, reporter Melanie Brown discovers how experts study the physics of these blazes from the Missoula Fire Sciences Laboratory. Presenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings

For the third year running, Iceland’s Reykjanes peninsula is experiencing another spectacular volcanic eruption. Volcanologist Evgenia Ilyinskaya has been out in Iceland witnessing the sight and getting samples of the noxious fumes. Across the rest of the Northern Hemisphere heat domes persist, bringing extreme weather ranging from wildfires to tornadoes. We keep on seeing that this year “is the warmest in 120,000 years”. But what does that mean? Two paleoclimatologists, Bette Otto-Bliesner and Jessica Tierney tell us more.And we’re going deep. Deep into the brain that is, with a newly-developed probe which is finer than a baby’s hair. Dr Anqi Zhang of Stanford University explains her delicate technology. Finally, new research suggests that SARS-CoV-2 could have arisen in the wild no more than four years ago, a mishmash of other viral genomes. Bioinformatician Jonathan Pekar discusses his new paper.Presenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings(Photo: Dr. Evgenia Ilyinskaya Credit: @E

As extreme heat returns to much of the world we hear the impact of last year’s heatwaves in Europe, where 62,000 people are estimated to have died. Joan Ballester, Associate Research Professor at Barcelona Institute for Global Health, discusses the figures from his latest paper and his concerns for the future. This week the European Court of Human Rights ruled in favour of middle-distance runner and Olympic champion Caster Semenya in a case related to testosterone levels in female athletes. Marnie Chesterton speaks to developmental biologist Dr Emma Hilton about what causes differences in sexual development and the impact they can have.Also, Kew Gardens is going digital. Millions of specimens are being made available to the world for the first time in an enormous digitisation project. Ella Hubber goes behind the scenes at Kew to see some of the precious specimens. Finally, the Indonesian government has banned a group of foreign scientists from conducting conservation research. Bill Laurance, Research Professo

Record-breaking global temperatures are accelerating Greenland ice melt at an alarming rate. Professor of glaciology Alun Hubbard has witnessed the melt first hand. He tells us how the ice sheet is being destabilised and what this could mean on a human level. Also, how safe are Japanese plans to dispose of nuclear waste from the Fukushima accident? We get reassurance from molecular pathology expert, Professor Gerry Thomas. And last week was a big one for cosmology news. We catch up on science behind the gravitational hum that permeates the Universe with astrophysicist with Dr Chiara Mingarelli. And we hear about the traces of ghostly neutrinos within our Galaxy from the principal investigator of the world’s largest neutrino detector, Professor Francis Halzen. Presenter: Roland Pease Producer: Ella Hubber(Photo: Meltwater forming on top of the Russell Glacier, Greenland)

We have entered a “permacrisis”, an extended period of instability and insecurity, fuelled not only by natural disasters but pandemics, climate change and war. This week, Science in Action is at the Royal Society as they host the All European Academies assembly on the importance of research in crises. Roland speaks to international experts on how research contributes to responding to and preparing for the multiple and entangled crises of our time. Presenter: Roland Pease Producer: Ella Hubber Editor: Richard Collings Production co-ordinator: Jonathan Harris (Photo: A man wearing a protective face mask walks past an illustration of a virus in Oldham, 3 August 2020 Credits: Phil Noble/Reuters)

Over the last week, news of “synthetic human embryos” has made headlines around the world. Science in Action is getting to the bottom of the sensational story. We talk to two of the researchers who have made the embryo models from stem cells in their labs; Professor Magdalena Zernicka-Goetz from the University of Cambridge and California Institute of Technology, and Professor Jacob Hanna from the Weizmann Institute of Science in Israel. They tell us how they made the embryo models, what their aims are, and their own ethical considerations. The scientific community is excited, but not surprised, by the breaking research. We hear how Dr Andreia Bernardo, group leader at Imperial College London, could use these structures in her future research. Finally, Director of the Reproductive Sociology Research Group at Cambridge University, Professor Sarah Franklin, and Professor of Law at Stanford University, Hank Greely, tackle the legal and ethical constraints on this kind of work, and why it is important for unde

As Pacific Ocean temperatures rise, a major El Niño is looming. Experts from the European Centre for Medium range Weather Forecasting, Magdalena Balmaseda and Tim Stockdale, join us to discuss how it is heating up the world and if it could herald in a new period of climate uncertainty.Last month, Roland stayed up all night to watch the spectacular explosion of supernova 2023ixf. Now, Dr Charlie Kilpatrick, a postdoctoral fellow at Northwestern University, has identified the star that blew up 21 million lightyears away. A similar star in our galaxy, the exceptionally bright Betelgeuse, has been acting strangely. Dr Andrea Dupree, a senior astrophysicist at the Center for Astrophysics, Harvard and Smithsonian, has been trying to figure out what is going on. Is this iconic star about to pop?And from ageing stars to ageing flies, researchers have published a cell-by-cell map of fruit flies throughout the life of the short lived creatures, showing how they change. Steve Quake, professor of bioengineering and profe

The origin of all complex life has been traced back 1.6 billion years as new molecular fossil records have discovered the fatty stains that our ancient single celled ancestors have left behind. Jochen Brocks, Professor of Geobiology at Australian National University, discusses the significance of these unique biological signatures. One billion years later, to a mere 462 million years ago, life on Earth was experiencing a boom of new species but we have very few fossil records to understand this era. Now, palaeontologists Dr Joe Botting and Dr Lucy Muir have found the most abundant deposit of soft bodied fossils from this time in a tiny Welsh quarry. Next, to the relatively recent past, 350,000 years ago, where remains found in a South African cave suggest that an extinct species of human, Homo Naledi, buried their dead. But Mike Petraglia, Professor of Human Evolution and Prehistory at the Max Planck Institute, doubts these claims. And in the modern day, the fungi which have colonised our soil for millions

The California Condor has been brought back from the brink of extinction by dedicated conservation efforts over the past 30 years. Now, this critically endangered species is the latest victim of the H5N1 bird flu which is racing round the world. California Condor co-ordinator Ashleigh Blackford and wildlife veterinarian Dr Samantha Gibbs from the US Fish and Wildlife Service discuss their last-ditch efforts to vaccinate the birds against H5N1.Huge 40,000 km plumes of water ice have been imaged erupting from Saturn’s moon Enceladus. Dr Sara Faggi, a postdoctoral Researcher in the Solar System Division at Nasa Goddard Space Flight Center, dives into this incredible new observation from the James Webb Space Telescope. Dr Pierre Galand from France’s Observatoire Océanologique de Banyuls has been part of a two-and-a-half-year expedition to sample the microorganisms in coral reefs across the world. His new research shows that this tiny life is much more diverse than previously understood and may be essential to lif

A star in the nearby Pinwheel Galaxy has exploded spectacularly into a supernova, dubbed SN 2023ixf. It is the brightest in a decade and it has got astronomers around the world into a frenzy. Science in Action hears from both amateur and professional astronomers alike as they scramble to collect exciting new images and data. Back on the ground, we hear from the Professor of Climate Change and Earth System Science at the University of Exeter, Tim Lenton about his new paper highlighting how rising global temperatures could push human populations from their homes.Contributors: Dan Milisavljevic, Assistant Professor in the Department of Physics and Astronomy, Purdue University. Dr Jane Clark, Trustee of the Cardiff Astronomical Society Bronco Oostermeyer, amateur astronomer Raffaella Margutti, Associate Professor in the Department of Physics and Astronomy, University of California, Berkeley Erez Zimmerman, Astrophysics PhD student, Weizmann institute of science Professor Avishay Gal-Yam, Head of Experimental A