The Doctor's Farmacy With Mark Hyman, M.d.

Dementia rates are skyrocketing, and cognitive decline is a growing concern. But what if you could actually grow a new brain? In this episode of The Dr. Hyman Show, I sit down with Alberto Villoldo, PhD, a medical anthropologist and shamanic healer (and author of Grow a New Brain), to explore the powerful intersection of ancient wisdom and cutting-edge neuroscience. In this eye-opening conversation, you’ll discover: The Amazonian secret to protecting the brain from dementia and cognitive decline. How certain plant compounds can activate your body’s natural detox and repair systems. The surprising role of gut health in brain regeneration—and how to reset your microbiome. Why serotonin depletion is wreaking havoc on mental health and how to restore balance. How shamanic healing and modern science align to create lasting cognitive health. Tune in to learn how you can take control of your brain health and unlock the potential for true regeneration. View Show Notes From This Episode Get Free Weekly Health T

There is a significant impact of food on brain health and overall well-being, with great importance placed on nutrient-dense, anti-inflammatory foods. Unfortunately, nutrient levels of modern crops are declining, but regenerative agriculture is helping to restore food quality. Specific brain-boosting foods such as leafy greens, small cold-water fish, and polyphenol-rich plants have an ability to reduce neuroinflammation, protect against cognitive decline, and enhance mental clarity. And, ultimately, identifying whole food sources of essential nutrients will support your entire body. In this episode, I discuss, along with Dr. Jeff Bland and Dr. William Li, practical tips on choosing the most nutrient-dense foods and how to harness their benefits for overall health. Dr. Jeff Bland is the founder of Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations—the immune system. Through Big Bold Health, Dr. Bland is advocating for the power of Immuno-Rejuven

Friendship isn’t just a feel-good concept—it’s essential for your health, happiness, and longevity. In this episode of The Doctor’s Farmacy, I sit down with world-renowned author and leadership expert Simon Sinek to explore the science and psychology of friendship—why we need it, how it impacts our biology, and what it takes to build deep, meaningful relationships in an increasingly disconnected world. In this fascinating conversation, we discuss: The surprising link between friendship and physical health—how loneliness drives inflammation, chronic disease, and even early death. Why your five closest friends determine your habits, health, and overall well-being. The social contagion effect—how behaviors like diet, exercise, and even emotions spread through friend groups. Why food, fitness, and lifestyle interventions won’t work unless we also address social health. The biggest friendship mistakes people make—and how to fix them. The missing conversation in longevity research—why friendship might be t

The rise in obesity and chronic disease over the years is alarming. Rather than genetics, it can be attributed to environmental and dietary changes, emphasizing the role of food quality over quantity. And while GLP-1 agonists like Ozempic may show some promise in addressing metabolic dysfunction, concerns about long-term effects, muscle loss, and cost highlight the need for a more nuanced approach. Ultimately, a holistic strategy that includes diet, lifestyle, and personalized interventions is essential for sustainable health improvements. In this episode I discuss, along with Dr. Tyna Moore and Calley Means, the complexity of obesity, moving beyond the simplistic "calories in, calories out" model to focus on factors like insulin resistance, ultra-processed foods, and metabolic dysfunction. With nearly three decades experience in the medical world, Dr Tyna Moore is a leading expert in holistic regenerative medicine and resilient, metabolic health. Traditionally and alternatively trained in science and medicin

What if instead of managing diabetes with drugs, we focused on reversing it? In this episode of The Dr. Hyman Show, I sit down with Sami Inkinen, CEO and co-founder of Virta Health, and Dr. Greeshma Shetty, a board-certified endocrinologist, to discuss an approach that’s transforming how we treat metabolic disease. They share groundbreaking research and real-world results that prove type 2 diabetes isn’t a lifelong sentence—it can be reversed with the right nutritional and care model. In this conversation, you’ll learn: Why mainstream medicine still treats type 2 diabetes as a progressive disease—even though science shows it’s reversible. How Virta Health is using a combination of nutritional therapy and continuous remote care to achieve Ozempic-level results, without the drugs. The critical role of personalized dietary interventions in reversing metabolic dysfunction. How a high-touch, tech-driven approach to patient care is leading to long-term success. The real cost of diabetes—not just for individual

Ultra-processed foods (UPFs) are identified as the leading cause of preventable death globally. These foods are chemically altered, stripped of their natural structures, and filled with additives, sugars, unhealthy fats, and preservatives, resulting in products that offer little to no nutritional benefit while contributing significantly to chronic disease. In this episode, I talk with Vani Hari and Dr. Shebani Sethi about why ultra-processed foods are not just a health risk—they are a public health crisis. Vani Hari is the food activist behind FoodBabe.com, a NY Times best-selling author of 4 books, founder of the organic products brand Truvani, and was named one of the “Most Influential People on the Internet” by Time magazine. Hari’s viral testimony before the US Senate sparked a massive movement to stop American food companies from poisoning their own citizens with ingredients they don’t use in other countries. Hari founded Food Babe to spread information about what is really in the American food supply. S

We all know sleep is important, but most of us don’t realize just how much it shapes our health—from metabolism and heart function to emotional well-being and even social connections. In this episode of The Dr. Hyman Show, I sit down with world-renowned sleep expert Matthew Walker, PhD, to uncover the science behind why sleep is one of the most powerful (and overlooked) tools for longevity. In this fascinating conversation, we discuss: Why Dr. Walker sees sleep as the foundation of good health and how it enhances the benefits of diet and exercise. The dramatic effects of even mild sleep deprivation on cognitive function and emotional health. How poor sleep can disrupt blood sugar regulation and increase the risk of chronic disease. The science behind deep sleep and its role in memory, learning, and brain detoxification. Simple, science-backed strategies to improve your sleep quality starting tonight. If you’ve ever struggled with sleep—or just want to optimize your health—this is an episode you won’t w

Highly processed vegetable oils, derived from seeds and beans, have become a dominant part of modern diets despite significant health concerns. Historical biases in nutrition science, influenced by the vegetable oil industry, have promoted these oils despite evidence from controlled studies showing negative health outcomes. These oils are unstable, prone to oxidation, and can create toxic byproducts, particularly when exposed to heat, contributing to inflammation and chronic diseases. Although they can lower LDL cholesterol, studies have shown that this reduction does not necessarily improve heart health and may increase risks for other conditions like cancer. In contrast, traditional fats like extra virgin olive oil and omega-3-rich foods offer more stability and health benefits, emphasizing the need for a balanced, minimally processed approach to dietary fats. In this episode, I talk with Nina Teicholz and Max Lugavere to explore the health impacts of different types of fats and oils, debunking misconceptio

Have you ever wondered if cholesterol-lowering statins are as effective as they claim? In this episode, Dr. Mark Hyman and Dr. Aseem Malhotra reveal the truth about these medications and the pharmaceutical industry’s influence on your health. Discover why lifestyle changes like diet and exercise can be more powerful than pills, and how misleading studies have shaped what we believe about heart health. In this episode, we discuss: Big pharma’s influence on medical research The benefits, drawbacks, and misuse of statins The Role of Insulin Resistance in Heart Disease The Importance of Lifestyle Over Medication The Impact of Meditation on Heart Disease View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal This episode is brought to you by BonCharge, Timeline, Paleovalley, and AirDoctor. Order BON CHARGE’s Max Red Light Therapy device today and get 15% off. Visit BonCharge.com and use code DRMARK for 15% off. Support essential mitochond

Our current food system is a national emergency. It’s intricately designed to confuse and mislead consumers, making healthy choices difficult and contributing to America’s chronic disease epidemic. In this episode, I sit down with Senator Cory Booker to delve into the systemic issues impacting our diet, food labeling, and the power of policy change.  In this episode, we discuss: How food packaging is designed to confuse or mislead consumers The link between the food system, chronic illness, and the unintended consequences of food policies that increase disease and healthcare costs. The harmful effects of ultra-processed foods The negative impact of industrial farming practices on the environment, soil health, and the nutritional quality of food The importance of personal health advocacy and broader public health initiatives to transform the food system, improve health outcomes, and reduce healthcare costs Uncover the truth behind our food politics and discover how informed choices can lead to a healthie

Do you ever feel like the more meds you take, the worse you feel? The problem might lie in how our healthcare system operates. In this episode, I sit down with Dr. Marty Makary to tackle the alarming rise of colon cancer among young people, explore how our microbiome plays a crucial role in preventing chronic diseases, and discuss the unsettling influence of the pharmaceutical industry on medical practices. From the impact of antibiotics on children to the hidden dangers of over-medication, we unpack the urgent need for more transparency and a shift towards addressing the root causes of illness. In this episode, we discuss: The alarming increase in colon cancer among young people The microbiome's impact on overall health, from regulating the immune system to influencing mood and metabolism The deep influence of pharmaceutical companies on medical research, education, and policy, often at the expense of patient care The long-term health consequences of early antibiotic use in children The overmedication o

Heart disease, cancer, and stroke are the leading causes of death—and premature death at that—in the US. These diseases all have several risk factors in common, like smoking, physical inactivity, and poor diet, which policy often views simply as personal choices. We need to begin looking at disease prevention beyond individual decision-making. In this podcast, I talk with Dr. Anand Parekh, Senator Bill Frist, and Dr. Dariush Mozaffarian on the need for government policymakers to address disease prevention. Dr. Anand Parekh is the Bipartisan Policy Center’s chief medical advisor, providing clinical and public health expertise across the organization, particularly in the areas of aging, prevention, and global health. As a US Department of Health and Human Services deputy assistant secretary for health from 2008 to 2015, he developed and implemented national initiatives focused on prevention, wellness, and care management. He is the author of Prevention First: Policymaking for a Healthier America. Senator Bill F

You’ve probably heard a lot about Robert F. Kennedy Jr., but beyond social media sound bites, do you really know where he stands on the issues shaping America’s health? Recorded last year when Kennedy was a presidential candidate, this episode of The Dr. Hyman Show provides a deep dive into his vision for improving the well-being of Americans. A vision Kennedy could put into action if confirmed as Secretary of Health and Human Services. Kennedy is the founder of the Waterkeeper Alliance, the world’s largest clean water advocacy group, and served as its longtime chairman and attorney. He also founded the Children’s Health Defense and led efforts to address chronic disease and toxic exposures. As a litigator, he was part of the team that successfully prosecuted Monsanto for glyphosate’s link to cancer. Tune in to explore Kennedy’s stance on tackling chronic disease, promoting regenerative farming, and improving the quality of the water we drink and the air we breathe. In this episode, we discuss (audio version

Food has become a more complex part of our lives than ever before. Much of what we think is food is actually many ingredients disguised as food, with entirely different, often negative impacts on the human body. Sadly, this is a greater problem here in the US than in other parts of the world, thanks to the food industry, corrupt intentions, and broken policies. Today, I talk about all this and more with my guest Jason Karp, whose personal experience of nearly going blind due to a toxic lifestyle led him to discover a different way; he made it his mission to get “back to human.” In this episode, we discuss: Jason’s personal health journey and why that has prompted him to take on the campaign against Kellogg’s (7:53) The unhealthy state of America’s food industry (22:42) How Kellogg’s has one cereal formulation for Canada and another for the US that is full of chemicals (26:07) The correlation between food dyes and ADHD, and the failure of Kellogg's pledge (29:04) The political aspect of food regulation an

What if the future of medicine isn’t about managing disease but erasing it? In this episode, I sit down with Dr. Darshan Shah to explore cutting-edge therapies like plasmapheresis and their potential to transform health and longevity. Together, we discuss how this innovative treatment reduces inflammation, supports recovery from long COVID, and improves aging biomarkers. Discover how personalized care and functional medicine could redefine how we approach healthspan and lifespan. In this episode, we discuss: An overview of plasmapheresis, an advanced medical procedure that replaces plasma to reduce inflammation and aid recovery from chronic conditions. The potential of therapies like plasmapheresis to alleviate conditions such as Alzheimer's, autoimmune diseases, and long COVID. Leveraging natural stressors like heat, cold, and oxygen therapy to enhance mitochondrial function and extend lifespan. Exploring the critical role of reducing inflammation to improve overall health and prevent age-related disease

Do you experience cravings for sugar and refined carbs? Do you regularly feel tired or sluggish or experience brain fog? Do you have joint pain, muscle aches, bloating, gas, sinus problems, skin problems, anxiety, depression or insomnia, or simply put, do you “feel like crap?” Most people, at some point in their lives, have experienced what I call FLC Syndrome—this is when you Feel Like Crap. Yet most people have no idea what causes it or how to fix it. The good news is that most of us are only a few days away from feeling well, ending sugar and carb cravings, and having control over our bodies.  In today’s episode, I talk about how to activate your body’s extraordinary healing and reparative systems with my 10-Day Detox Diet. The 10-Day Detox addresses foundational gaps missing in our modern diet, supplements that support our natural detoxification systems, minerals and amino acids that promote relaxation and deep rest, and a dietary protocol that works by taking out the wrong foods and focusing on the right

Did you know many chronic diseases—like type 2 diabetes, anxiety, and fatigue—can be reversed? In this episode of “The Dr. Hyman Show,” Dr. Rangan Chatterjee breaks down how lifestyle changes, mindset shifts, and trusting your body can transform your health. We explore the hidden role of diet, stress, sleep, and movement in reversing illness naturally, while exposing what Western medicine often overlooks. If you’re ready to reclaim your health, this episode is your starting point. In this episode, we discuss: Reversing Type 2 diabetes The dangers of ultra-processed foods and how cutting them out for as little as 10 days can significantly improve energy, sleep, and overall health. How socioeconomic factors, corporate influence, and environmental toxins contribute to chronic disease​. The power of journaling, meditation, and routines to create a sense of control in an unpredictable world. Practical, no-cost tools—like mindfulness, whole-food eating, and lifestyle tweaks—that anyone can use to improve their

Food is more than just fuel – every bite we take has a profound impact on our biology. In this episode, I explain the principles of the Pegan diet, emphasizing the importance of quality, nutrient-dense foods. Joining me are some incredible guests: Dr. Cindy Geyer, a renowned expert in functional medicine, and Dr. Elissa Epel, a leading stress researcher. Together, we’ll explore how chronic stress and poor sleep are intricately connected to major health issues like obesity, diabetes, and neurodegenerative diseases. Learn how specific dietary choices can serve as powerful medicine, improving your overall health and longevity. Plus, explore actionable tips and expert insights on integrating these health-boosting foods into your daily routine. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal Full-length episodes of these interviews can be found here: How to Follow the Pegan Diet What Is Driving Your Poor Sleep and How Can You Fix It? How

We’ve all been there: one too many drinks and the next morning feels like a nightmare. But why does alcohol make us feel so terrible? In this episode of “The Doctor’s Farmacy,” I’m uncovering the surprising reasons behind hangovers and how you can avoid them. Get ready for expert tips on hydration, supplements, and the real truth about that ‘hair of the dog’ myth. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman’s Weekly Longevity Journal This episode is brought to you by Rupa University, Wonderfeel, and AX3. Rupa University is hosting FREE classes and bootcamps for healthcare providers who want to learn more about Functional Medicine testing. Sign up at RupaUniversity.com. Head over to getwonderfeel.com and experience the science of feeling younger. It’s more than wonderful—it’s Wonderfeel. Get 20% off your first order of AX3's astaxanthin at ax3.life/hyman with code HYMAN at checkout.

Like most things in life, when it comes to optimizing metabolic health, a nuanced perspective can help. Rather than viewing it as a black-and-white issue, we can take into consideration the big-picture social context we’re facing that encourages ultra-processed foods, obesity, and lifelong medication as well as the micro-level of what people are experiencing as individuals and understanding how to help them when all else fails.  Today I’m thrilled to sit down with Dr. Tyna Moore and Calley Means for a grounded discussion that explores both sides of the spectrum, and everything in between.  In this episode, we discuss: The controversial discussion of GLP-1 agonists like Ozempic, weighing the pros and cons of these new drugs in treating obesity and metabolic crises (3:34) Challenging the notion of treating obesity with drugs like Ozempic (10:35) An unsettling revelation about the push for using Ozempic in children (12:04) Digging deeper into GLP-1 research and some of the benefits (32:51) Why are children