Science In Action

Nasa scientists have observed that the Earth’s energy imbalance has doubled in just 15 years. As greenhouse gas atmospheric concentrations have risen, so too has the difference between the total amount of energy being absorbed from the sun, and the total amount being reradiated back into space. Meanwhile, as we all heat up, scientists at the LIGO Gravitational Wave Observatory have managed to do something very cool with their mirrors. Such is the precision with which the detectors have been engineered, they have managed to effectively reduce the temperature of one of the big 10kg reflectors to such an extent that it betrays its quantum state, as if it were simply one big subatomic particle. So what? Roland Pease finds out. Presenter: Roland Pease Producer: Alex Mansfield(Photo: Giant sun in the horizon. Credit: Getty Images)

Dr. Clare Jolly and colleagues have been looking at how the first of the major covid variants – alpha - evolved to be more transmissible. Whilst a lot of attention has been on the spike binding areas of the virus and the effectiveness of antibodies from either vaccine or prior infection, their preprint paper this week reports how the virus evolved an ability to inhibit our bodies innate virus response once it has infected a cell.Prof Dan Shugar and colleagues have been studying the conditions that led to the tragic rock and ice avalanche in February in Chamoli, Uttarakhand. 27 million cubic meters of rock and ice broke off the steep mountainside and plummeted almost 2km down into the valleys below. Using satellite, seismic and video data the scientists have investigated the sequence of events that led to the tragic deaths of 204 people in the floods that followed. It was a thankfully rare combination of geography and geology and events, but highlights the care that should be taken when building the growing n

Researchers map where the riskiest areas are for viruses to jump from bats into humans. Also, synthetic bacteria with unnatural DNA, and the origin of the humble watermelon.David Hayman of Massey University in NZ and colleagues have published in the journal Nature Food a study highlighting areas of the world where zoonotic transmission of coronaviruses are most likely to occur between humans and bats of the type most suspected of being the origin of the current SARS CoV2 virus. There are a lot of hotspots combining fragmented forest, livestock farming, human habitation, and populations of horseshoe bats. It is, as he says, just part of the evidence suggesting a natural origin in the areas of northern south-east Asia and southern China.Jason Chin, Wes Robertson and team at the Laboratory of Molecular Biology have been tinkering with their work on synthetic organisms. By rewriting the dictionary of DNA itself, their new molecular alphabet is able to encode far more elaborate and innovative functions than even n

The latest Nyiragongo eruption was not entirely unexpected, the volcano’s lava lake inside the crater had been building up for years. Local volcanologists say it was only a matter of time before an eruption occurred. The big concern was where the flank of the volcano would be breached as the city of Goma rests under the volcano and there are potential fissures even within the town. However there are still questions over the effectiveness of seismic monitoring in the area, North Kivu. The Goma observatory has been unable to carry out this work due to a lack of funding. And monitoring is further complicated by the region’s long running civil war, with rebel groups often camped around the volcano. We hear from Dario Tadesco and Cindy Ebinger. Who have both been monitoring developments. Cyclone Yass was the second Cyclone to hit India within a week. Are these events becoming more common and are they related to rises in global temperatures? Climatologist Roxy Koll has been monitoring the situation. Greenland’s

A brain-computer interface allows a severely paralysed patient not only to move and use a robotic arm, but also to feel the sensations as the mechanical hand clasps objects . We hear from Jennifer Collinger at Pittsburgh University’s Rehab Neural Engineering Labs. And Nathan Copeland, who has been controlling the robotic arm with his thoughts via a series of brain implants. Ralph Baric of the University of North Carolina tells us about the development of a multi-component vaccine that would be effective not just against the current coronavirus outbreak and its variants, but also future outbreaks from SARS-like coronaviruses that we don’t even know about yet. Blood clots, thromboses, have been a problem for a small number of people following Covid vaccination Paul Knöbl, and a team of medics in Vienna have worked out the link between vaccination and clot development. They now have a method to treat such clots – so they should not be fatal. And how did fungi and plants come to live together? Symbiotic rela

We wouldn’t drink dirty water so why do we put up with polluted air? Researchers are calling for a major rethink on our attitude to air quality. Professor Lidia Morawska, from the Queensland University of Technology, says attention to air quality during the Covid pandemic has shown how levels of airborne disease can be reduced. Sam Wilson from the UK Medical Research Council, University of Glasgow Centre for Virus Research has been investigating genetic mechanisms associated with susceptibility to Covid infection. His team has identified a molecule that detects SARS-COV-2 when it starts to replicate in our cells. However, not all humans have this protective mechanism, which may help explain why some people become very ill with Covid and others have little if any symptoms.Many Europeans lack this protective molecule, whereas the vast majority of Africans have it. The difference can be seen in cell cultures. However, the lack of diversity in the cells used in experiments worldwide can be a serious problem wh

Analysis of the 78,0000-year-old fossil of a Kenyan boy reveals he was likely buried with care and attention, the body wrapped and laid to rest supported on a pillow. Maria Martinon-Torres, of the National Research Centre on Human Evolution in Burgos, Spain, and a team from Kenya and Germany used techniques from paleontology and forensic science to reveal his story from the fragile remains.A promising malaria vaccine is to enter trials which could lead to it being used globally to vaccinate children. Merheen Datoo, Oxford University’s Jenner Institute, explains malaria vaccines have been in development for 100 years. Research from these helped covid vaccine development and the success of covid vaccines may now help to speed up the rollout of malaria vaccines.Covid vaccines may also help to treat those who have symptoms of long covid – a range of immune system issues that develop sometimes months after the initial infection. Yale University immunologist Akiko Kawasaki is embarking on a research project to ass

When Apollo 11 astronaut Michael Collins – who passed away this week – looked down on the earth from lunar orbit during those days in 1969, he saw more ice and a smaller liquid ocean than you would see today. Of the 200,000 glaciers outside of the polar and Greenland ice sheets, their melting in the last two decades accounts for about a fifth of the sea level rise we are also seeing. Thus according to a paper published this week in the journal nature by, amongst others Bob McNabb of Ulster University who describes to Roland how and why these numbers are more certain than others before. As fellow earth observation expert Anna Hogg adds, the work synthesises years of data from almost half a million images of glaciers taken from space, and provides our best handle yet on our accelerating loss of this finite and dwindling natural feature.Researchers at Kew in the UK and in Sierra Leone have rediscovered a species of coffee plant once thought lost. As Marnie Chesterton reports, climate change threatens many coffee

As Covid cases surge almost beyond belief in India, how much is to do with social distancing, and how much to do with the mutations to the original virus?Ramanan Laxminarayan talks to Roland from Delhi about ways in which the huge second wave could and could not have been predicted and avoided. Suggestions of the latest variant to make the headlines, B1.617, have got virologists such as Ravindra Gupta working hard to identify the clinical significance of the latest combinations of mutations.In the journal Science, Stephen Chanock of the US Cancer program reports work with colleagues in Ukraine looking at the long footprint of radiation dosing from the Chernobyl nuclear disaster, 35 years ago this week. In the first of two papers, they find a definite footprint of radiation damage accounting for the many sad cases of thyroid cancer in people alive in the region at the time. But in another study, they looked at whether any higher level of mutations could be detected in the germlines of children conceived subseq

Two weeks ago several G7 leaders called for an international treaty on Pandemic Preparedness for the future. This week 175 prominent leaders called for lifting the IP on vaccine design. And former UK PM Gordon Brown called on the G7 to finance vaccines for the world in the next two months. But are there technical difficulties that limit the pace of manufacture? Anthony McDonnell is an economist at think tank Centre for Global Development who has been looking at the problem since last year. He suggests, amongst other things, one limit is the human expertise in manufacturing these brand-new technologies, with another being a level of vaccine nationalism that is seeing a lack of exports of components involved in manufacture.Professor Trudie Lang heads the University of Oxford’s Global Health Network, and looks at health research across the world. She says in most countries there is no lack of public health or infrastructure potential for rolling out the vaccines, if only the supply existed. The volcano that er

On Wednesday the EU’s EMA and UK’s JCVI announced a suspected correlation between vaccination and an extremely rare type of blood clot. Prof Sabine Eichinger is a co-author of a new paper suggesting a link with vaccination or the immune response to Covid vaccination and suggests the name VIPIT for the condition. One of her patients died at the end of February having presented with a rare combination of symptoms – blood clots and a low blood platelet count. Sabine tells Roland the dots they have managed to join in the story so far.Scientists at Fermilab in the USA posted four papers and announced an exciting development in particle physics that might lift the curtain on science beyond the Standard Model. Their measurement of something known as g-2 (“gee minus two”, just fyi), by measuring with phenomenal accuracy the magnetic properties of muons flying round in circles confirms a 20-year old attempt at a similar value by colleagues at Brookhaven. At the time, it was breathtaking but suspicious. Muons, rather l

After last year’s first wave of covid-19 in the UK, individuals who had been discharged after hospitalisation suffered higher rates of coronary and respiratory disorders, and even diabetes subsequently over 140 days. As Dr Ami Banerjee of University College London explains, out of 48,000 cases, patients who had had acute covid-19 were four times more likely to be readmitted and 8 times more likely to die. Ami’s team suggests in their paper published in the British Medical Journal that diagnosis, treatment and prevention of post-covid syndrome needs an integrated approach.In France, researcher Xavier Montagutelli describes how his team has observed that unlike the original virus, some of the newer Variants of Concern can infect mice in laboratories. They do not show serious illness, but nevertheless host the virus in their lungs. Whilst infection is unlikely in natural environments and not yet observed in the wild, it does show how the viral variants can extend the host range, perhaps leading to more opportuni

Sightseers and social media scrollers have flocked to the slopes of Fagradalsfjall, a volcano erupting 40 kilometres west of the Icelandic capital Reykjavik. Having produced less than 1 square kilometre of lava this eruption could be deemed relatively minor, allowing bystanders to get up close and personal. Among the hubbub, you might also spot Dr Evgenia Ilyinskaya from University of Leeds, just one of the researchers measuring and observing the event from an alarmingly small distance. Her interest is more in the invisible toxic gases and trace elements being emitted from one of the deepest magma eruptions in recent times than the more cinematic molten rock. This week scientists working on results from the Large Hadron Collider at CERN announced intriguing evidence (NB “evidence” – not yet a definite discovery) of physics beyond our current understanding. Everything we can detect directly in the universe is made from a few basic building blocks, fundamental particles. These particles are governed by four uni

In the UK thousands of scientists have signed open letters to the UK government protesting cuts to international funding announced this week. Abruptly and severely, the cuts may end hundreds of international collaborations between UK scientists and colleagues around the world working on health, climate change, disaster resilience, sustainability and many development topics. Professor Jenni Barclay is a volcanologist at the University of East Anglia, and is one of the organisers of the protest. At the University of Cape Town, Dr Chris Trisos is the director of the Climate Risk Lab at the African Climate and Development Initiative, one of the authors of the IPCC 6th assessment, and has just learned his funding will be terminated, as the UK’s Royal Society must trim its output in this area by two thirds. Professor Otteline Leyser is CEO of UKRI – the UK’s main research funding agency, and will have to work out what will happen to over 900 projects currently under way.Antarctica Iceberg A74 break away Earlier thi

Last week a fireball lit up the sky of western England. Locals and professionals scoured the countryside for any surviving precious fragments of meteorite, and thanks to them some bits of the earliest solar system are now in London’s Natural History Museum. And as an excited Sara Russell, Merit Researcher in Cosmic Mineralogy tells us, examples of carbonaceous chondrite – the soft, loamy type that fell in Winchcombe – such as this, are a rare and special chunk of luck.10 years on from the Japanese Tsunami Exactly a decade ago the disastrous huge wave caused by an earthquake at sea struck the coast of Japan, causing death and devastating consequences. The flood defences have been rebuilt to replace the ones swept away. But could new ways of spotting tsunamis beyond the horizon be, well, just over the horizon? Giovanni Occhipinti of the Paris Geophysics Institute tells Roland about his technique of looking at disruptions in the highest levels of the atmosphere - using the slight twinkle in a beam from a GPS or

One of our most complete ancient ancestor’s fossils has been transported to the UK from South Africa in order to be scanned at the Diamond Light Source. Roland Pease investigates what these scans could reveal about the human story. Professor Corinne Le Quéré explains how she managed to look past the 7% reduction in human emissions caused by the pandemic in 2020 to reveal the impact of the Paris Climate agreements, and explains what more needs to be done. Roland speaks with anthropologist Dr. Rolf Quam, who has studied the inner ears of fossilised Neanderthal skulls to reveal they may have evolved the ability to hear the complex sounds of spoken language separately to our own species. Dr. Emma Hodcroft discusses the Brazilian P1 COVID 19 variant that is spreading around the world. (Image: Little Foot Skull. Copyright: Diamond Light Source Ltd)Presenter: Roland Pease Producer: Rory Galloway

Although vaccines will go a long way to reducing the number of cases of Covid, there’s still a need for other approaches. One of these could be an engineered biomolecule, designed by virologists Anne Moscona and Matteo Porotto, that blocks SARS-CoV-2 precisely at the moment it tries to enter cells in the nose and upper airways. Roland Pease talks to Anne Moscona about this “molecular mask”. We’re already beginning to see really encouraging analyses showing that Covid vaccines are performing as well in the real world as was promised by last year’s trials. Shane Crotty of the La Jolla Institute for Immunology discusses progress so far and the question of one dose or two with Roland. Lives can be saved if there’s an early warning system for earthquakes and tsunamis. Seismologist Zhongwen Zhan at CalTech has been experimenting with a newly installed 10,000 km cable laid along the Pacific coasts of north and south America by Google, all the way from Los Angeles to Santiago. What he was looking for were subtle chan

A paper in the BMJ shows that deaths from Covid 9 are being massively overlooked in Zambia. The new data come from post-mortem tests at the University Hospital mortuary in Lusaka, showing that at least 1 in 6 deaths there are due to the coronavirus; many of the victims had also been suffering from tuberculosis. Chris Gill of Boston University’s Department of Global Health, and Lawrence Mwananyanda, chief scientific officer of Right to Care, Zambia, discuss their findings with Roland Pease. New variants of concern continue to be reported, such as the one labelled B 1 1 7 in the UK, or B 1 351 identified in South Africa. Geneticist Emma Hodcroft, of the University of Bern, talks about seven variants that have been found in the US. Although all these variants are evolving from different starting points, certain individual mutations keep recurring – which suggests they have specific advantages for the virus. Her co-author Jeremy Kamil, of Louisiana State University Health Sciences Center in Shreveport, explains

On 18th February the Perseverance rover should land on Mars. Katie Stack-Morgan of NASA’s Jet Propulsion Lab tells Roland Pease about the technological advances that mean that the spacecraft should be able to land in Jezero Crater. Imperial College geologist Sanjeev Gupta discusses what this crater can reveal about the history of life on the red planet. After months of negotiations, and weeks of work on the ground, a team brought together by the World Health Organisation has just concluded its first attempts to find out the origins of SARS-Cov2 in Wuhan. Peter Daszak, who has worked closely with Chinese virologists in the past, briefed Roland Pease on what had been discovered. The South African government has announced that it will not be rolling out the Astra Zeneca Covid vaccine as it appears it is not very effective against the dominant strain in the country. Helen Rees, of Witwatersrand University and a member of South Africa’s Health Products Regulatory Authority, explains that the ‘ban’ is an overstate

A new trial is about to start in the UK, seeing if different vaccines can be mixed and matched in a two-dose schedule, and whether the timing matters. Governments want to know the answer as vaccines are in short supply. Oxford University’s Matthew Snape takes Roland Pease through the thinking. Despite the numbers of vaccines being approved for use we still need treatments for Covid-19. A team at the University of North Carolina is upgrading the kind of manufactured antibodies that have been used to treat patients during the pandemic, monoclonal antibodies. Lisa Gralinski explains how they are designing souped-up antibodies that’ll neutralise not just SARS-CoV-2, but a whole range of coronaviruses. Before global warming, the big ecological worry that exercised environmentalists was acid rain. We’d routinely see pictures of forests across the world dying because of the acid soaking they’d had poisoning the soil. In a way, this has been one of environmental activism’s success stories. The culprit was sulphur in