Empowered Patient Podcast

James Hereford, President and CEO of Fairview Health Services, describes this Minnesota-based healthcare system's $600 million turnaround and the importance of focusing on people and processes, not just technology changes. Addressing staff shortages, quality of care, and patient experience led to finding a holistic approach that improved financial outcomes and changed the culture in a sustainable way. Investments have been made in community programs like food access and vaccination events, recognizing the impact of social determinants of health on patient outcomes. James explains, "When doing this, we have to think about sustainability, and there are things that you can do, like mass layoffs, that can change the short-term economics of an organization. They're just not sustainable. The work hasn't gone away. You haven't changed the nature of work, and we really tried to focus on the people in the process side of this and really make our focus on our processes." "The other problem with thinking only about th

Steve Butts, Co-Founder and CEO of Arrivo BioVentures, is a biopharmaceutical company focused on developing therapies that target the root causes of disease rather than just treating the symptoms. Their drugs treat major depressive disorder and acute pancreatitis through novel epigenetic mechanisms of action. Sex-based differences were observed in clinical trials where the drug SP-624 showed efficacy in females but not in males, which could lead to a paradigm shift in how depression is treated in men and women. Steve explains, "We've evolved over time at Arrivo and with our previous companies. What we're excited about right now is the fact that we have two drugs. One called SP-624 or Forvisirvat is the generic name, and the other one is code-named RABI-767. And as we've gotten into the science behind these drugs, what we're finding is that we're not just treating the symptoms of a disease, but we're really trying to get at what's causing the disease fundamentally and trying to make an impact there. And I thi

Daniel Blumenthal, VP of Strategy at MDClone, is building synthetic data models to mimic real patient data without the need to protect the identity of individuals. This type of data is being utilized in drug discovery and development, building predictive tools and new care models, and to better understand biases in clinical trials making them more representative. AI tools play an essential role in generating and validating synthetic data as well as integrating it into various processes and environments. Daniel explains, "Synthetic data means different things to different people. So I definitely would want to start with sharing what it usually means to MDClone, which is creating data based on real populations of patients, real patient data. Learning from that real patient data, extracting essentially the statistics from that data, understanding the relevant patterns that exist inside that data, and then, based on the statistics alone, generating a brand-new set of data, a brand-new set of people, and the synt

Rick Geoffrion, Founder and CEO of Cyrano Therapeutics, is developing a drug to restore olfactory function due to post-viral loss of smell and taste. As a result of COVID-19, there has been a significant increase in the number of people affected by long-term smell and taste loss, with no effective pharmaceutical options previously available. Smell loss can also be an early indicator of neurodegenerative conditions, suggesting future applications of the intranasal spray that aims to directly restore function to the olfactory receptor neurons. Rick explains, "Taste and smell have a really strong connection, actually. First of all, they're two out of the five basic senses that we have as human beings. When you lose your sense of smell, people actually perceive that they've lost about 80% of their sense of taste. Now, technically, you're not losing your sense of taste. We actually just give our tongue too much credit. Our tongue is able to detect sweet, sour, salty, bitter, and umami. That's all it detects, and

Loren Larsen, CEO and Co-Founder of Videra Health, is using AI-powered technology to improve the patient-provider connection and monitor patient health, particularly mental health, in an empathetic and conversational way. The video-based AI platform engages patients in regular check-ins to assess mental and physical conditions and detect subtle changes in behavior, tone, or language that could indicate issues like suicidal ideation or movement disorders. Data from patient encounters is also providing insights to clinicians and helping patients and providers better understand the connection between mental health and chronic conditions. Loren explains, "We started Videra Health recognizing this challenge that when a patient isn't with their doctor, they lose connection. You go to your doctor, you get good care, you leave. There's never been a good way to follow up or check in with patients to see how they're doing. And so we've really applied AI to this for the last six years since we started the company to ch

David Fischel, CEO and Chairman of the Board of Stereotaxis, is advancing the ability of surgical robotics, particularly in the field of minimally invasive catheter-based procedures. Stereotaxis is developing the use of robotic technology to improve precision and accessibility in endovascular surgeries with a unique mechanism that allows surgeons to control the tip of the catheter. The adoption of surgical robotics for endovascular procedures will expand as remote access is made available and safety concerns are addressed for previously impossible-to-treat conditions.  David explains, "We build advanced robots that allow physicians to do minimally invasive catheter-based procedures with greater precision and safety. We're kind of pioneering that area of robotic surgery. We've seen other areas of medicine benefit significantly over the last decade or two from advanced robotic technologies. And there's a whole field of catheter-based endovascular cardiovascular procedures where we're still using handheld cathe

Craig Limoli, Co-Founder and CEO of Wellsheet, is streamling workflows for clinicians by providing better access to patient data and improving care coordination across care teams.  Wellsheet is integrated into existing health records to provide a seamless experience to users and help to reduce "pajama time" for doctors by reducing the amount of end-of-the-day work needed to document patient encounters.  Wellsheet uses AI and natural language processing to surface the most relevant information for clinicians and generate documentation, reducing time spent and improving efficiency. Craig explains, "Wellsheet is a care team, co-pilot that serves physicians as well as other clinicians with better access to all of the data they need to make treatment decisions for patients, as well as easier coordination across the whole care team. So we're really designed as a company and as a product to support a broad array of clinicians, both physicians, nursing case managers, and surface the data most relevant to them in the

Aron Knickerbocker, President and CEO of Aulos Bioscience,  is on a mission to extend the lives of cancer patients through safer and more effective immunotherapy using AI and machine learning to accelerate drug discovery and optimization. The company's lead drug candidate is an antibody that was designed using AI to harness the power of interleukin-2 to activate the immune system against tumors.  The advantages of AU-007 over previous IL-2 therapies include the ability to selectively activate tumor-fighting immune cells while avoiding toxicity due to vascular leakage. Current trials are underway in advanced melanoma and non-small cell lung cancer, which are showing the potential for durable responses and immune memory. Aron explains, "So Aulos has really been founded to carry out a mission to extend the lives of patients with innovative, safe, and ultimately effective cancer immunotherapy. And you mentioned IL-2, which is the naturally occurring protein that we're seeking to harness and redirect in productiv

Aniq Rahman, Founder and CEO of Fabric, a technology company that uses an AI-powered platform to support health systems, health plans, and employers, to streamline patient care, scheduling appointments, and receiving virtual care. The system can triage patients, route them to appropriate care, and simplify the provider workflows to improve operational efficiency, drive better patient outcomes, and reduce provider burnout. Fabric is taking an integrated approach to healthcare technology rather than offering individual point solutions in order to create a seamless experience for patients and providers. Aniq explains, "We started Fabric about four years ago now in 2021 in the midst of the pandemic. And we're a technology company fundamentally. So, Fabric builds technology. We work primarily with health systems, but also with health plans and employers, to really help bring together the care journey of a patient. So that's everything from helping a patient find care, triage their symptoms, get virtual care, and

James Keppel, Founder and CEO of Sarana Health, is focused on an integrated healthcare model that addresses chronic health challenges and preventative care. By providing personalized care, advanced lab testing, and one-on-one coaching with healthcare professionals, Sarana aims to fill the gaps in the traditional healthcare system, which often focuses on sick care rather than keeping people healthy. The company's integrated care model looks at the interconnected body systems to identify underlying causes of health issues, rather than just treating symptoms. James explains, "What we provide is a totally personalized client-led and client-centric approach to wellness. We do that through an advanced series of lab tests and also you get to actually talk to the people who care for you, which I know is rare.  Everything is very much about you and the person that you are, as opposed to charts and graphs about past history and that sort of thing with other doctors. So we get very dialed into the person."   "We've got

Muffy Walker is a psychiatric nurse, mental health advocate, and author with a focus on bipolar disorder and Alzheimer's disease. As a founder of the Bipolar Foundation and through her work with the Alzheimer's Association, Muffy is working to raise awareness, reduce the stigma often associated with these conditions, and bring resources to patients and caregivers. Based on her personal experiences with family members with bipolar and Alzheimer's, Muffy has published her latest novel, Memory Weavers to help others deal with the challenges of diagnosing, treating, and supporting complex mental conditions. Muffy explains, "I am a psychiatric nurse. I have a master's in psychiatric nursing from the University of Pennsylvania, and I worked in that space, mostly working in the PTSD area. And then I had a family member who was diagnosed with bipolar disorder. This was over 23 years ago. At that time, there were very few resources available, so three other women and I decided to launch what was then called the Calif

Michael Reidy, a senior consultant at Interaction Associates, discusses the challenges and opportunities facing both new and experienced doctors, given the rise of virtual doctor visits and telemedicine, as well as the use of AI tools in the healthcare environment. While new doctors often possess strong technical skills, they may lack the interpersonal skills necessary to communicate effectively with patients. Experienced doctors may need a refresher on active listening skills to adapt to screen technologies.  While technology and AI tools can enhance the patient-doctor relationship by providing data and insights, the human interaction remains essential. Michael explains, "We are a 55-year-old company that has worked with clients ranging from healthcare to nuclear power to finance services. So we're providing tools to organizations to empower leaders, managers, individual contributors, and coaches to encourage performance and enhance capability." "New physicians are such a brilliant audience for us. I think

Allan Sheffield, Co-Founder of Gene By Gene,  offers genetic testing to provide insights into an individual's risk for various diseases, including cancer and rare genetic disorders, allowing for more proactive and preventative healthcare.  Analysis of pharmacogenomic data, which examines how an individual's genes influence their response to medications, also helps doctors prescribe the most effective treatments and avoid potential side effects. Integrating genetic data into electronic medical records and using AI to simplify the interpretation of results is enabling doctors and patients to improve patient outcomes, reduce healthcare costs, and use polygenic risk scores to provide more comprehensive insights into an individual's health. Allan explains, "Gene By Gene is one of the largest genomic sequencing or genetic tech companies in the US, and we do everything from whole genome sequencing to offering hereditary cancer screening, predictive cardiovascular risk, and things like pharmacogenomic testing to see

Sandy Saggar, CEO of Connexall, aims to solve the challenge of disparate and unconnected technologies in hospitals that lead to inefficient workflows, data silos, and increased cognitive load on clinicians. Connexall's connected care platform helps integrate hospital systems and medical devices to improve communication, automate workflows, save time for clinicians, and enhance patient outcomes. The need for a connected hospital is becoming increasingly clear, as it helps break down technical barriers and improve interoperability. Sandy explains, "So the challenge today and has been a challenge for some time is that hospitals have disparate technology pieces all over the place, and between technologies and medical devices, they're not connected to one another. It means less automation, silos of data, and just workflows that don't help clinicians and staff do their work around patient care. So when you look at all of these medical devices, clinical systems can be connected, which can really improve those workf

Dr. George Sledge, Executive VP and Chief Medical Officer of Caris Life Sciences, is using advanced molecular testing, including DNA, RNA, and protein analysis, to identify specific mutations and characteristics of a patient's tumor, allowing for more personalized and targeted treatment. The company is developing liquid biopsies to detect cancer early, identify minimal residual disease, and assess the potential for future cancer development. Caris has a database of over half a million patients whose tumors have undergone next-generation sequencing, allowing them to draw increasingly accurate conclusions. The future of precision oncology is expected to involve broader and earlier use of next-generation sequencing as the cost of the test continues to decrease significantly. George explains, "Caris Life Sciences is a molecular diagnostics company. Patients and their physicians send us tumor samples that can be obtained either from the primary tissue or from a distant recurrent site. When they come to us, we do

Kirk Huntsman, Chairman, CEO, and Co-Founder of Vivos Therapeutics, is focused on the connection between obstructive sleep apnea and Alzheimer's disease, the challenges of diagnosing sleep apnea, and the importance of sleep testing in treating the root causes of sleep disorders. The Vivos oral appliance is a non-invasive way to address the breathing disorder OSA and resulting sleep issues. Proper nasal breathing and airway development from a young age can help prevent the onset of sleep apnea and help preserve brain health. Kirk explains, "Sleep apnea is an interesting condition that has only been actively researched for the last 60 years. It was really only identified and started showing up in the medical literature in the mid-1960s. And so we really have about a 60-year run at trying to figure out what this condition is, what it affects, what's comorbid with it, etc. We're now pushing 40 plus conditions, which are comorbid with sleep apnea, and every time we find another condition that is coexistent with s

Marianne De Backer is the CEO of Vir Biotechnology, a company developing treatments that harness the power of the immune system to fight serious infectious diseases and cancer. Vir Biotechnology’s current clinical trials include a registrational program in chronic hepatitis delta, a rare, often fatal liver disease, as well as two Phase 1 trials of PRO-XTEN™ dual-masked T-cell engagers (TCEs), one targeting HER-2 and the other targeting PSMA, each in heavily pre-treated cancer patients. TCEs have shown tremendous potential but have been limited due to toxicity challenges. The PRO-XTEN™ technology keeps the TCEs masked until they reach the tumor microenvironment, potentially mitigating the toxicity of TCEs and allowing them to unleash their tremendous potential to destroy cancer cells.  Marianne explains, “Vir Biotechnology is an immunology company, and that means that we are really developing treatments that take advantage of the power of basically the patient's own immune system to fight a variety of diseases

Evan Steele, Founder and CEO of online reputation management company rater8, emphasizes the importance of online reviews for healthcare providers and how patients are increasingly relying on reviews to select a doctor. The key to generating reviews is to actively ask for feedback and acknowledge receipt of comments. Negative reviews and low-star ratings can encourage practices to respond to comments, improving the patient experience and demonstrating to patients that the practice cares. Evan explains, "Now, you look in your insurance guide to see which providers in your area accept the insurance. There's a Facebook group. You might ask, Who do I go to see for my shoulder that hurts for an orthopedic surgeon? You ask your friends and family, your PCP gives you some names, and you start going down the list. And what's changed is if you call that first doctor on the list and they don't have great reviews, you might not even call them, but let's say you call them and they have a convenient time, and a location i

Elli Kaplan, CEO and Co-Founder of Neurotrack,  emphasizes the importance of early cognitive assessment and the potential of digital tools in advancing the screening process for cognitive decline and neurodegenerative diseases. Screen-based assessment tools can provide more efficient, accurate, and objective screening compared to traditional pen and paper tests. Integrating cognitive screening into primary care settings can lead to early intervention when lifestyle changes can help maintain brain health and slow the progression of conditions like Alzheimer's disease. Elli explains, "We are focused on screening for cognitive decline, and that includes mild cognitive impairment all the way through to Alzheimer's disease, working largely with primary care providers to help them then make a diagnosis of cognitive decline or Alzheimer's in their clinics and refer patients on to get better treatment." "Historically, there have been tests that have existed in the universe that are pen and paper tests that measure c

Dr. Sandra Silberman, Chief Medical Officer at CNS Pharmaceuticals, has developed new therapies for glioblastoma that can cross the blood-brain barrier to reach brain tumors. Their lead drug candidates have been modified to slip into the membranes to inhibit tumor growth and attack the cancer cells. The anthracycline-based and taxane-based drugs are showing efficacy in clinical trials and are not showing the cardiotoxicity associated with anthracyclines. Sandra explains, "Anthracyclines are characteristically cardiotoxic. And we have just conducted a study of over 160 patients who have received this, and some of them for quite a long period of time. And we have not seen any cardiotoxicity. So we have one of the anthracyclines that is the first to actually cross the blood-brain barrier without any help from other mechanisms, and it also doesn't cause cardiotoxicity. So we have a really open field to be able to further develop this drug. And we know that this drug, based on all of our preclinical studies, is ve