Dr. Howard Smith Oncall

Vidcast:  https://www.instagram.com/p/DPa0nyEDeLQ/The drug is orforglipron, and it comes as a pill you swallow daily rather than as a shot you give yourself weekly.  Researchers at Canada’s McMaster University tested the pill in a phase 3 gold standard randomized, double-blinded multinational study of 3127 subjects reported in the New England Journal of Medicine.The data at week 72 revealed that, for those taking the largest daily dose of 36 mg, 55% lost 10% or more of their body weight, 36% lost 15% or more, and 18% lost 20% or more.  Those on orforglipron also enjoyed better body composition stats, improved blood pressures, as well as better triglyceride and  non-HDL cholesterol numbers.The drug did have the same side effects as other peptide GLP-1 medications like semaglutide and tirzepatide.  Those included bloating, heartburn, nausea, constipation, and diarrhea.  The drug is convenient and a likely god-send for needle haters.https://www.nejm.org/doi/full/10.1056/NEJMoa2511774#glp1 #orforglipron #oral #di