The Doctor's Farmacy With Mark Hyman, M.d.

The Gut-Brain Connection: Why Your Mental Health Starts in the Microbiome

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Synopsis

The connection between mental health and metabolic health is far deeper than once believed, with growing evidence showing a powerful, bidirectional relationship. Inflammation, poor diet, and gut dysfunction are now recognized as key drivers of both physical and psychological illness—often hiding in plain sight. By addressing root causes such as blood sugar imbalances, nutritional deficiencies, and microbiome disruption, many chronic mental health conditions can improve or even resolve. This emerging science challenges the traditional separation of mind and body, pointing instead to an integrated approach where healing the body becomes essential for healing the brain. Recognizing this link is crucial in shifting the future of mental health care. In this episode, I discuss, along with Dr. Chris Palmer and Dr. Shebani Sethi, why our diet is so closely related to the state of our mental health. Dr. Chris Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health. He is the Di