Dr. Howard Smith Oncall

  Vidcast:  https://youtu.be/kxtrGTKuUn8   A University of Houston spinoff company has developed a nasal spray that triggers robust CoVid antibodies and cellular immunity while being storable without freezing for up to 11 months.  The vaccine has two components: spike protein and a nanoparticle adjuvant called nanoSTING.   The components are stored separately with the nanoSTING refrigerated and the spike protein in freeze-dried, powdered form.  Just before use, the spike protein is reconstituted, mixed with the nanoSTING, and sprayed in the nose as a single dose vaccine.  This vaccine formulation  makes storage and distribution around the world much simpler than with the mRNA vaccines.   This nasal vaccine induces strong lining immunity within the nose where CoVid usually enters the body.  The levels of IgA secretory antibody and killer T cells protect against viral penetration and proliferation but only so far in a mouse model.  Work is underway to initiate human trials.   https://www.cell.com/iscience/full