Dr. Howard Smith Oncall

  Vidcast:  https://youtu.be/V395dwF4DTs   Short Shorts are quickie reports about cutting edge medical and healthcare discoveries.  They’re worth knowing about this 2nd week of April, 2022.   CAR-T chimeric antigen receptors have proven effective immunotherapy for blood system cancers such as leukemias.  They haven’t worked as well on solid tumors.  Now a Dutch research group working with BioNTech, the developers of the Pfizer CoVid vaccine has found that CAR-T cells kill solid cancers better when they are sensitized to the protein CLDN6 that is found on the surfaces of testicular, ovarian, and endometrial cancer cells.  That sensitization can be now accomplished using mRNA.  A phase 1 trial of 14 patients with advanced cancers showed a 86% response rate.  Very promising.   https://aacr.ent.box.com/s/c5vdgvlj128qojzmuqgwuj2uz8mipqsy     There is a sweet spot for bedtime if you want to have the lowest risk of cardiovascular disease.  A UK study of over 88 thousand Brits shows that those hitting the bedsheets b