Neurology® Podcast

This month’s Delayed Recall episode includes interviews on drug pricing. The episode starts with Dr. Jason Crowell’s interview with Dr. Gordon Smith from September 26, 2017 on orphan drug pricing. Following this clip, we have the full-length interview from the December 5, 2017 episode where Dr. Ted Burns speaks with Dr. John Mytinger on the drug Achtar for infantile ataxia. Next, in an interview from the July 4, 2017 podcast, Dr. Stacey Clardy focuses her interview with Dr. Dennis Bourdette on new immunotherapies. In the fourth and final interview, Dr. Ted Burns and reporter Ike Swetlitz discuss drug pricing practices and the different players in determining drug prices, which first aired in the May 1, 2018 episode of the podcast.

1. Featured Article: Nusinersen in spinal muscular atrophy type 1 patients older than 7 months: a cohort study2. What’s Trending: MRI-guided thrombolysis for stroke with unkown time of onset (WAKE-UP study)In the first segment, Dr. Ted Burns talks with Dr. Laurent Servais about his paper on safety and efficacy of nusinersen treatment in patients with SMA type 1 older than 7 months. In the second part of the podcast, we are featuring a discussion with Dr. Jim Siegler and Dr. Christian Gerloff on the results of the WAKE-UP stroke trial.DISCLOSURES: Dr. Servais has served as scientific consultant in the S.A.B of Roche, Biomarin, aTyr Pharma, Dynacure, Biogen, Bamboo, Sarepta, and Avexis; has received speaker honoraria gave lecture sponsored by Biomarin, Biogen, and Sarepta; holds patents as co-inventor of the Moviplate device, and of Actimyo; has consulted for Bamboo therapeutics, Pfizzer, Anagenesis, Avexis, and Dynacure; has received research support from NHS, Valerion, Dynacure, Avexis, Biogen, Roche, FP7 pro

1. Antiepileptic Drug Clearances during Pregnancy and Clinical Implications for Women with Epilepsy2. AAN Position Statement: Lawful physician-hastened deathIn the first segment, Dr. Derek Bauer talks with Dr. Paula Emanuela Voinescu about her paper on antiepileptic drug (AED) clearances during pregnancy and the relationship between AED serum concentration and seizure frequency. In the second part of the podcast, we are featuring a discussion with Dr. Jason Crowell and Dr. James Russell on the recent AAN position statement regarding lawful physician-hastened death.DISCLOSURES: Dr. Voinescu has received speaker honoraria from SUNOVION, and has received research support from American Academy of Neurology, Susan Spencer Clinical Training Fellowship. Dr. Russell has received funding for travel from the Mexican Academy of Neurology; receives publishing royalties from Neuromuscular Disorders (McGraw-Hill, 2nd ed, 2015) and honorarium for a published article in Continuum Peripheral Neuropathy 2017; has received comp

1. Cerebello-spinal tDCS in ataxia: A randomized, double-blind, sham-controlled, crossover trial2. What’s Trending: Emerging therapies for spinal muscular atrophy and Duchenne muscular dystrophyDr. Jeff Ratliff talks with Dr. Alberto Benussi about his paper on cerebellar anodal and spinal cathodal transcranial direct current stimulation as a therapeutic approach for reducing symptoms in patients with neurodegenerative ataxia. In the second part of the podcast, we are featuring a discussion with Dr. Ted Burns and Stat reporter Adam Feuerstein on two emerging therapies for spinal muscular atrophy and Duchenne muscular dystrophy.DISCLOSURES: Dr. Ratliff has received speaker honoraria from Teva and US WorldMeds LLC; is the deputy editor for the Neurology Podcast; has been a consultant for UCB Pharmaceuticals, US WorldMeds LLC, Medscape, and Retrophin Inc; and has served on speakers' bureaus for Teva and US WorldMeds LLC. Dr. Burns has served on scientific advisory boards for Argenx, UCB, and CSL Behring; has rece

1. Featured Article: Dual antiplatelet therapy pretreatment in intravenous thrombolysis for acute ischemic stroke2. What’s Trending: Recurrent glioblastoma treated with recombinant poliovirusDr. Dan Ackerman talks with Dr. Andrei Alexandrov about his paper on dual antiplatelet therapy pretreatment. In the second part of the podcast, Dr. Kait Nevel focuses her interview with Dr. Darrell Bigner on treatment for recurrent glioblastoma. DISCLOSURES: Dr. Alexandrov has served on a scientific advisory board and consulted for Cerevast Therapeutics, Inc.; has served on editorial boards for Cerebrovascular Diseases and Interventional Neurology; holds a patent, and receives associated license fee and royalty payments, for "Therapeutic Methods and Apparatus for Use of Sonication to Enhance Perfusion of Tissue” (US patent 6,733,450 - May 11, 2004); receives publishing royalties for Cerebrovascular Ultrasound in Stroke Prevention and Treatment (Futura / Blackwell Publishing. 2003.), Cerebrovascular Ultrasound in Stroke Pr

1. Practice guideline recommendations summary: Disorders of consciousness2. Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human HerpesvirusIn the first segment, Dr. Jeff Burns talks with Dr. Joseph Giacino about the AAN Guideline update on disorders of consciousness. In the second part of the podcast, we are featuring a discussion with Dr. Jason Crowell and Dr. Joel Dudley discuss the detection of human herpesvirus genes in in a large cohort patients with Alzheimer disease.DISCLOSURES: Dr. Burns has served on the DSMB for NIH-funded trials (non-profit entities); serves on the editorial board for Journal of Alzheimer's Disease; has consulted for Grifols, USA; has served on Eli Lilly Amyvid Speaker's Bureau; and has received research support from Eli Lilly, Avid Radiopharmaceuticals, Toyama Chemical Company, Merck, Biogen, AbbVie, Novartis, vTv Therapeutics, Janssen, and NIH (R01AG058557, R01AG053312, R01AG034614, R01AG03367, R01AG043962,

For the September 2018 Delayed Recall episode, we are featuring recordings of in-person interviews that took place at the April 2018 AAN Annual Meeting. All interviewees were plenary speakers who gave talks throughout Annual Meeting week. These recordings originally appeared as “What’s Trending” segments in July 2018 (July 17, 24, and 31, respectively). In the first interview, we will hear Dr. Alberto Espay speak with Dr. Jeff Lichtman about connectomics. Next, Dr. Stacey Clardy interviews Dr. Michael Wilson about his talk on next-generation sequencing and diagnosing meningitis and encephalitis. Last, Dr. Alberto Espay discusses the matter of who should be the primary caregivers for functional disorder patients with Dr. Andrea Leigh Haller and Dr. David Perez.

1. How Early Can We Diagnose Alzheimer’s Disease (And Is It Sufficient)? 2. What's Trending: Updates to the International Classification of Headache Disorders (ICHD-3)Dr. Stacey Clardy talks with Dr. Ronald Petersen about his paper on Alzheimer disease diagnosis. In the second part of the podcast, Dr. Tesha Monteith focuses her interview with Dr. Jes Olesen on what's new in the 3rd edition of the International Classification of Headache Disorders (ICHD-3). The full ICHD-3 can be found at https://www.ichd-3.org/wp-content/uploads/2018/01/The-International-Classification-of-Headache-Disorders-3rd-Edition-2018.pdfDISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Petersen receives publishing royalties from Mild Cognitive Impairment (Oxford University Press, 2003); has consulted for Roche Incorporated, Merck, Genentech, Biogen, and GE Healthcare (presentation); and has received research support from the National Institute on Aging (U01-AG006786, P50-AG

1. Featured Article: Silent infarct is a risk factor for infarct recurrence in adults with sickle cell anemia2. What’s Trending: Neuropalliative Care: Priorities to move the field forwardDr. Justin Sattin talks with Dr. Lori Jordan about her paper on silent infarct and the risk of infarct recurrence in adults with sickle cell anemia. In the second part of the podcast, Dr. Maisha Robinson focuses her interview with Dr. Claire Creutzfeldt on neuropalliative care.DISCLOSURES: Dr. Jordan serves on the editorial boards of the Journal of Child Neurology, Pediatric Neurology and Stroke; and has received research support from Dr. Creutzfeldt has received research support from NINDS (K23 NS099421-01A1) and Cambia Health Foundation's Sojourn Scholars Program. Dr. Sattin and Dr. Robinson reports no disclosures.

1. Neurology® Clinical Practice: Safety and efficacy of plasma exchange in pediatric transverse myelitis2. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA (POINT study)Dr. Stacey Clardy talks with Dr. Benjamin Greenberg about his paper on therapeutic plasma exchange in a cohort of pediatric transverse myelitis patients. Next, Will Rondeau interviews Dr. Clay Johnston about findings from the POINT study on clopidogrel and aspirin in acute ischemic stroke.DISCLOSURES:Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR).Dr. Greenberg has received travel funding from the Transverse Myelitis Association; has filed has filed patents on the use of antibody biology in multiple sclerosis; has consulted for Novartis, Alexion, and EMD Serono; and has received research support from Medimmune, Chugai, Medday, Genentech, NIH (RO1 NS071463), Unviersity of Texas Southwestern, Guthy Jackson Foundation, PCORI, Transverse Myelitis Association, and the National MS Soci

1. Diagnosing Cerebral Ischemia with Door-to-Thrombolysis Times Below 20 Minutes2. What’s Trending: Tenecteplase versus Alteplase before Thrombectomy for Ischemic StrokeDr. Jimmy Berthaud speaks with Dr. Perttu Lindsberg about his paper on the accuracy and consequences of rapid stroke diagnostics in a neurological emergency department. In the second segment of the podcast, Dr. Kevin Barrett interviews Dr. Bruce Campbell about the EXTEND-IA TNK trial of tenecteplase for patients with ischemic stroke.DISCLOSURES: Dr. Berthaud reports no disclosures. Dr. Lindsberg serves as Assistant Editor for the medical journal DUODECIM; serves as chairman of the ad hoc committee on Current Therapy Guidelines in Stroke for the Finnish Medical Society; and has recieved research support for Helsinki University Hospital District, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation, and the Signe and Ane Gyllenberg Foundation. Dr. Barrett has received research support from Axovant Sciences, Inc., the Virginia Cent

1. Organic solvents and MS susceptibility: Interaction with MS risk HLA genes 2. AAN 2018 Controversies in Neurology plenary: Andrea Leigh Haller and David Perez discuss primary caregivers for functional disorder patientsDr. Stacey Clardy talks with Dr. Anna Hedström about her paper on exposure to organic solvents and the associated risk of developing multiple sclerosis, followed by a discussion with Dr. Alberto Espay, Dr. Andrea Leigh Haller, and Dr. David Perez on who should be the primary caregivers for functional disorder patients. The second interview was originally recorded at the AAN Annual Meeting in Los Angeles.DISCLOSURES: Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Drs. Hedström, Leigh Haller, and Perez report no disclosures. Dr. Espay serves as Associate Editor for the Journal of Clinical Movement Disorders; serves as an editorial board member of Parkinsonism and Related Disorders and The European Neurological Journal; serves on the scientific ad

1. Non-invasive vagus nerve stimulation as acute therapy for migraine: The randomized PRESTO study2. AAN 2018 Hot Topics plenary: Michael Wilson discusses metagenomics for diagnosing CNS infectionsDr. Teshamae Monteith talks with Dr. Cristina Tassorelli about her paper on vagus nerve stimulation for treating migraine, followed by a discussion with Dr. Stacey Clardy and Dr. Michael Wilson on next-generation sequencing and diagnosing meningitis and encephalitis. The second interview was originally recorded at the AAN Annual Meeting in Los Angeles.DISCLOSURES: Dr. Monteith serves as an editorial advisory board member for Neurology Now and receives research support from the NIH. Dr. Tassorelli has served on scientific advisory boards for Allergan Inc., ElectroCore LLC, Eli-Lilly and Company, Novartis, Teva Pharmaceutical Industries Ltd; has received funding for travel or speaker honoraria from Novartis, Allergan Inc, and Teva Pharmaceutical Industries Ltd; serves on editorial boards for Journal of Headache and Pa

This month’s Delayed Recall episode consists of the Migraine Lesson of the Week series posted each week in January 2018. The episode starts with Dr. Teshamae Monteith’s interview with Dr. Stephen Silberstein (January 9, 2018) about updates in chronic migraine risk factors and management, followed by her interview with Dr. Jelena Pavlovic (January 16, 2018) on the interplay between migraine and hormones. Next, Dr. Monteith focuses her interview with Dr. Stuart Tepper on neuromodulation (January 23, 2018). In the fourth and final interview, Dr. Monteith and Dr. Benjamin Friedman discuss emergency management of migraine (January 30, 2018).

1. Featured Article: Longitudinal analysis of impulse control disorders in Parkinson disease2. What's Trending: Frontiers in Neuroscience plenary interview from 2018 Annual MeetingThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the July 17, 2018 issue of Neurology. In the first segment, Dr. Jason Crowell talks with Dr. Alexis Elbaz about his paper on impulse control disorders in Parkinson disease. In the second part of the podcast, Dr. Alberto Espay focuses his interview with Dr. Jeff Lichtman on connectomics. The interview was recorded at the 2018 AAN Annual Meeting in Los Angeles.DISCLOSURES: Drs. Crowell and Lichtman reports no disclosures. Dr. Elbaz has received research support from Agence nationale de la recherche (ANR), Agence nationale de sécurité du médicament et des produits de santé, JPND (Joint Programme - Neurodegenerative Disease Research), Institut de santé publique (IRESP), French ministry of agriculture, and Anses (government

Dr. Derek Bauer talks with Dr. Jacqueline French about her paper, a summary of a recent practice guideline on the treatment of new-onset epilepsy. 

Dr. Brian Eckerle talks with Dr. Rob van de Graaf about his paper on conscious sedation vs local anesthesia during endovascular treatment for ischemic stroke. 

Dr. Stacey Clardy talks with Dr. Shelly Benjaminy about her paper on patients’ perspectives from the chronic cerebrospinal venous insufficiency clinical trial in Canada. 

Dr. Alex Menze interviews Dr. Kelly Gwathmey about her paper on a new quality of life measure for diabetic polyneuropathy. 

The Delayed Recall episode for June takes a look at recent guidelines and developments in the field of multiple sclerosis treatment. In the first interview, Dr. Stacey Clardy and Dr. Alexander Rae-Grant discuss recent practice guidelines for multiple sclerosis, and talk about Dr. Rae-Grant’s paper regarding these guidelines. This interview first aired on April 24, 2018. The second interview, from the May 15, 2018 episode, features Dr. Clardy speaking with Dr. Riley Bove about her recent paper on rituximab treatment during pregnancy. Next, hear Dr. Clardy speak with Dr. Raed Alroughani about relapse occurrence of MS during pregnancy, in an interview that appeared in the March 6, 2018 episode. In the conclusion to this month’s episode, Dr. Mark Keegan and Dr. Gavin Giovannoni discuss the topic of alemtuzumab treatment for multiple sclerosis patients. This interview first appeared on April 18, 2017.